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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(6): 1971-1975
DOI: https://doi.org/10.20546/ijcmas.2019.806.234


Studies on the Effect of Bacteriophage Lysate of Pasteurella multocida on Serum Protein Levels in Rabbits
Yanglem Pushpa and Hari Mohan Saxena*
Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University (GADVASU), Ludhiana 141004 Punjab, India
*Corresponding author
Abstract:

The study was undertaken to evaluate the protein levels in rabbits affected by a lysate vaccine developed from Pasteurella multocida grown under iron-restricted conditions and lysed by a bacteriophage. Serum proteins include immunoglobulins and complement which mediate humoral immune response and an assessment of protein levels can be of clinical relevance being an indicator of humoral immune response. Two groups of rabbits were immunized with lysate vaccine (LV) and conventional alum precipitated killed HS vaccine (CV) and blood was collected at various days post – immunization (DPI). The serum protein concentration in lysate vaccinated rabbits (2.74 + 1.436) was significantly higher (p<0.05) than the conventional vaccinated rabbits (0.73 + 0.230) at 30 DPI. The increased total protein could be due to increase in various components like the acute phase proteins, immunoglobulins, lymphokines, mediators of inflammation and complement activation because of the antigenic stimulus provided by the phage lysate.


Keywords: Hemorrhagic septicemia, Pasteurella multocida, Bacteriophage, Phage lysate, Vaccine, Host response
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How to cite this article:

Yanglem Pushpa and Hari Mohan Saxena. 2019. Studies on the Effect of Bacteriophage Lysate of Pasteurella multocida on Serum Protein Levels in Rabbits.Int.J.Curr.Microbiol.App.Sci. 8(6): 1971-1975. doi: https://doi.org/10.20546/ijcmas.2019.806.234