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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(6): 1521-1528
DOI: https://doi.org/10.20546/ijcmas.2019.806.183


Pharmacokinetics of Marbofloxacin after Single Intravenous Administration in Calves
Neelam Dinodia, Pratishtha Sharma*, Ashok Gaur and Mamta Meena
Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Science, RAJUVAS, Bikaner – 334001 (Rajasthan, India)
*Corresponding author
Abstract:

Marbofloxacin is a third generation quinolone developed exclusively for veterinary use. The disposition kinetic profile of marbofloxacin was generated after a single intravenous bolus injection in male Sahiwal calves (n = 5) at the dose level of 2 mg.kg-1 body weight. Marbofloxacin concentrations in plasma were determined by microbiological assay using Escherichia coli MTCC 443 as the test organism. The plasma concentration–time profile following intravenous administration was best described by a two-compartment open model. The plasma drug concentration ≥ 0.12 μg.ml-1 was detected at 24 h. The distribution (t½α) and elimination (t½β) half-lives were 0.12 ± 0.01 h and 5.73 ± 0.15 h, respectively. Area under plasma drug concentration-time curve (AUC), mean residence time (MRT), apparent volume of distribution (Vdarea) and total body clearance (ClB) were 16.49 ± 0.58 μg.ml-1.h, 8.00 ± 0.19 h, 1.01 ± 0.03 L.kg-1 and 0.12 ± 0.00 L.kg-1h-1, respectively. Marbofloxacin at the dose rate of 2 mg.kg-1 body weight once daily by intravenous route is sufficient in calves for treatment of susceptible bacterial infections.


Keywords: Calves, marbofloxacin, pharmacokinetics
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How to cite this article:

Neelam Dinodia, Pratishtha Sharma, Ashok Gaur and Mamta Meena. 2019. Pharmacokinetics of Marbofloxacin after Single Intravenous Administration in Calves.Int.J.Curr.Microbiol.App.Sci. 8(6): 1521-1528. doi: https://doi.org/10.20546/ijcmas.2019.806.183