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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
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Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(6): 1308-1315
DOI: https://doi.org/10.20546/ijcmas.2019.806.158


A Study of Scrub Typhus, Its Various Clinical Presentation and Antigenic Types Detected by IFA
S.R. Sujatha* and S. Deepa
Department of Microbiology, Mysore Medical College & research Institute Mysore, Karnataka, India
*Corresponding author
Abstract:

Scrub typhus is a bacterial zoonosis caused by Orientia tsutsugamushi. Timely diagnosis is necessary as the disease presents with varied signs, symptoms and may progresses to multiorgan dysfunction syndrome. Scrub typhus shows wide antigenic variation, one of the methods for its detection is IFA. There is scarcity of data regarding antigenic variations of Orientia tsutsugamushi which is of importance in our country. About 100 serum samples were collected from patients who had fever for > 7days (excluding other causes of fever). IFA detecting IgM antibodies to Orientia tsutsugamushi was done. Among 100 samples, 27 were positive by IFA. Common symptoms were abdominal pain (81.48%), vomiting (77.7%), myalgia (70.07%). O/E patients showed hepatomegaly (70.37%), lymphadenopathy (66. 6%), splenomegaly (51. 8%) and thrombocytopenia (77.77%) and Anaemia in (44.4 %) patients. Raised SGOT (81. 48%), SGPT (77.77%) with varied LFT was observed. Common Antigenic type was Gilliam (37. 03%), Karp (18.51%). Diagnosis of Scrub typhus is a challenge as it presents with various signs and symptoms. Antigenic variation of Orientia tsusugamushi will help in knowing a circulating strain which can be of use for a sensitive point of care test.


Keywords: Scrub typhus, IFA, Orientia tsutsugamushi
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How to cite this article:

Sujatha, S.R. and Deepa, S. 2019. A Study of Scrub Typhus, Its Various Clinical Presentation and Antigenic Types Detected by IFA.Int.J.Curr.Microbiol.App.Sci. 8(6): 1308-1315. doi: https://doi.org/10.20546/ijcmas.2019.806.158