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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(6): 1123-1134
DOI: https://doi.org/10.20546/ijcmas.2019.806.139


Glactomannan Index as a Rapid Diagnostic Tool for Invasive Pulmonary Aspergillosis in Patients with Chronic Lung Diseases
Asmaa Nasr Eldin Thabet1* and Kamal Abdel Sattar Ata2
1Department of Microbiology and Immunology,
2Department of Chest Diseases, Faculty of Medicine, Sohag University, Egypt
*Corresponding author
Abstract:

Invasive aspergillosis has increased considerably in recent years; this serious infection was primarily described in severely immunocompromised patients and patients with moderate levels of immune suppression. We conducted this study on 85 patients admitted to the chest department and chest ICU with severe exacerbations of chronic lung diseases in the period from April 2018 to April 2019. We collected tracheal aspirates BAL fluid and blood samples for isolation of Aspergillus spp. by convectional culture and assay of galactomannan level in these samples using ELISA. Aspergillus spp. was isolated from (14.3%) of tracheobroncheal aspirate samples, (11%) BAL samples and (2.4%) blood samples. Aspergillus fumigatus represented (70%) of isolates while Aspergillus niger represented (25%). Galactomannan antigen was positively detected in (9.4%) of serum samples, (22%) of tracheobronchial aspirates, and in (22.2%) bronchoalveoalar lavage fluid samples. The sensitivity (52%) and specificity (48%) of culture were much lower than the sensitivity and specificity of galactomannan detection (92%) and (85%) respectively. proven IA patient category represented (2.4%), while Probable IA represented (22.4%), and possible IA represented (22.2%). invasive aspergillosis could be a cause of exacerbation in patients with chronic chest diseases and a cause of their unresponsiveness to relevant treatment. Galactomannan antigen detection is a rapid sensitive diagnostic test of IA in those patients that helps the clinicians to rapidly diagnose IA and start antifungal therapy.


Keywords: Invasive aspergillosis, Galactomannan antigen, Invasive fungal infections
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How to cite this article:

Asmaa Nasr Eldin Thabet and Kamal Abdel Sattar Ata. 2019. Glactomannan Index as a Rapid Diagnostic Tool for Invasive Pulmonary Aspergillosis in Patients with Chronic Lung Diseases.Int.J.Curr.Microbiol.App.Sci. 8(6): 1123-1134. doi: https://doi.org/10.20546/ijcmas.2019.806.139