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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(6): 1079-1085
DOI: https://doi.org/10.20546/ijcmas.2019.806.133


Characterization and Antifungal Susceptibility Profile of Candida Species Isolated from Candiduria Cases in a Tertiary Care Hospital, Kolkata
Reena Ray (Ghosh)1*, Piyali Haldar2 and Mitali Chatterjee1
1Department of Microbiology, R.G. Kar. Medical College & Hospital, Kolkata, India
2Department of Microbiology, Govt. Medical College, Diamondharbour, Kolkata, India
*Corresponding author
Abstract:

Candida species are unusual cause of urinary tract infections in healthy individuals, but common in hospital setting or among patients with predisposing factors. The isolation of Candida from urine is challenging both for clinician and microbiologist as to whether the candiduria represents colonization or urinary tract infection. Species identification of Candida is also important as non albicans Candida are on rise in recent years which are more resistant to antifungal drugs and as a result morbidity and mortality is also increasing. The objective of this study was to determine the prevalence of Candida species causing UTI, analyze various risk factors associated with candiduria and their antifungal susceptibility pattern. A total of 1860 urine samples from clinically suspected cases of urinary tract infection were analysed in a tertiary care Hospital during a period of one year. 105 Candida isolates were obtained from these urine samples and species identification was done following standard laboratory protocol. Antifungal susceptibility testing was performed by disc diffusion method following CLSI guideline M-44A. Among all suspected cases of urinary tract infection, candiduria was diagnosed in 5.64% cases. Candida tropicalis 44(42%) was the predominant isolate followed by Candida albicans-38(36%), Candida glabrata-14(13%), Candida parapsilosis-07(07%) and Candida krusei-02(02%). The antifungal susceptibility pattern showed that Candida isolates were more resistant to Fluconazole-39(37%), followed by Itraconazole-30 (28.5%). Fluconazole resistance was more common among non albicans Candida (41%) than Candida albicans (29%). Our study reflects a change in trend with shift towards non-albicans candida replacing Candida albicans as the predominant cause of candiduria. Non albicans Candida species are more resistant to antifungal drugs compared to C. albicans. Therefore species identification of Candida isolates along with their antifungal susceptibility pattern is important to guide clinicians for better therapeutic options which will reduce both morbidity as well as financial burden on patients.


Keywords: Antifungal susceptibility profile, Candida Species, Candiduria
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How to cite this article:

Reena Ray (Ghosh), Piyali haldar and Mitali Chatterjee. 2019. Characterization and Antifungal Susceptibility Profile of Candida Species Isolated from Candiduria Cases in a Tertiary Care Hospital, Kolkata.Int.J.Curr.Microbiol.App.Sci. 8(6): 1079-1085. doi: https://doi.org/10.20546/ijcmas.2019.806.133