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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(6): 722-726
DOI: https://doi.org/10.20546/ijcmas.2019.806.085


Disseminated Cutaneous Histoplasmosis in a 30-Year-Old Male HIV-Positive Patient: A Rare Case Report
Vikas Kumar1, Astha2*, Yatendra Chahar1 and Arti Agrawal1
1Sarojini Naidu Medical College, Agra, India
2F. H. Medical College, Agra, India
*Corresponding author
Abstract:

Histoplasmosis is a systemic mycotic infection caused by Histoplasma capsulatum, a dimorphic fungus. Although histoplasmosis can occur in immunocompetent persons, but immunocompromised individuals, such as people with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS), are at high risk of developing disseminated disease. In AIDS patients, mortality may approach 50%, due to disseminated histoplasmosis, especially in those with severe manifestations. We present a case of disseminated histoplasmosis in a 30-year-old, HIV-positive male patient on antiretroviral treatment, who presented to the Skin outpatient clinic with multiple papulonodular lesions on the face, neck, trunk and ulcers in oral cavity. General complaints included fever, malaise and weight loss, along with hepatosplenomegaly on examination. Investigations revealed pancytopenia, altered liver function and renal dysfunction. CD4 cell count was 72 cells/µl. The patient was started on Amphotericin B for 2 weeks as induction therapy followed by oral itraconazole as maintenance therapy. Histoplasmosis is rarely reported from India, which may be on account of its varied clinical presentation and lack of awareness among dermatologists, hence disseminated histoplasmosis should be considered as a differential diagnosis in an immunocompromised patient presenting with cutaneous lesions, as it is necessary for the early diagnosis and proper management of the patient.


Keywords: Histoplasma capsulatum, Disseminated histoplasmosis, HIV, AIDSs
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How to cite this article:

Vikas Kumar, Astha, Yatendra Chahar and Arti Agrawal. 2019. Disseminated Cutaneous Histoplasmosis in a 30-Year-Old Male HIV-Positive patient: A Rare Case Report.Int.J.Curr.Microbiol.App.Sci. 8(6): 722-726. doi: https://doi.org/10.20546/ijcmas.2019.806.085