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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(1): 184-193
DOI: http://dx.doi.org/10.20546/ijcmas.2017.601.023


Bacteriological Profile and Antimicrobial Resistance of Blood Culture Isolates from a 350 bedded Hospital Lucknow, India
Manjusha Pandey1*, Devendra Niranjan2 and R.C. Pande3
1Department of Microbiology, Vivekananda Polyclinic & Institute of Medical Sciences, Lucknow, India
2Department of Microbiology Career Institute of Medical Science and Hospital Lucknow, India
3Department of Microbiology, Saifai Medical College, Etawaa, Uttar Pradesh, India
*Corresponding author
Abstract:

Blood stream infections can lead to life threatening sepsis and require immediate antimicrobial treatment. Blood culture is an essential tool for the investigation of clinically suspected bacteremia or septicemia. A timely detection of organism type and antibiotic susceptibility testing is critical for the effective treatment of the patient. Illness associated with blood stream infection ranges from self-limiting infections to life-threatening sepsis that require rapid and aggressive antimicrobial treatment. The present study was to describe the profile of bacterial isolates from the blood cultures in a Polyclinic and to know their antibiotic resistance, so that the study can provide guidelines for choosing an effective antibiotic therapy in cases of septicemia. This is a retrospective study of 2452 blood samples collected from clinically suspected cases of bacteraemia reviewed over a period of one year in vevekananda polyclinic & institute of medical Sciences. 2452 blood samples collected over a year from clinically suspected cases of bacteremia were studied. The isolates were identified by standard biochemical tests and antimicrobial resistance patterns were determined by CLSI guidelines 2013. Positive cultures were obtained in 752 (30.6%) cases. Among culture positive isolates, Gram-negative bacteria accounted for 51.2% cases; most common being Klebsiella spp (23%) followed by Escherichia coli (20%) and Acinitobacter (04%). Of the pathogenic Gram-positive isolates, Enterococci (20%) was the predominant isolate followed by Coagulase negative Staphylococci (16%). Maximum Gram-negative isolates were sensitive to Colistin (95%) and Imipenen Meropenem (90). Daptomycin sensitivity was reported in 100% Staph. aureus and CONS and Vancomycin 90% in Enterococcus spp. This study provides information on antibiotic resistance of blood isolates. It may be a useful guide for physicians initiating empiric therapy and will help in formulation of antibiotic therapy strategy.


Keywords: Blood Stream Infection, Antibiotic resistant, Vancomycin Resistant Enterococci, Antimicrobial therapy, Septicemia.
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How to cite this article:

Manjusha Pandey, Devendra Niranjan and R.C. Pande. 2017. Bacteriological Profile and Antimicrobial Resistance of Blood Culture Isolates from a 350 bedded Hospital Lucknow, India.Int.J.Curr.Microbiol.App.Sci. 6(1): 184-193. doi: http://dx.doi.org/10.20546/ijcmas.2017.601.023