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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(1): 116-124
DOI: http://dx.doi.org/10.20546/ijcmas.2017.601.015


Vitality of Pro-Inflammatory Cytokine, Scavenger Receptor Proteins and Atherosclerotic Plaque Markers in Risk Prediction of Diabetic Nephropathy
V. Khot1, K.S. Yadav1*, V.A. Haldankar1 and A.K. Bhutey2
1Department of Biochemistry, School of Medicine, D Y Patil University,Navi Mumbai-400706, India
2Dr.PDM Medical College, Amravati-444603, India
*Corresponding author
Abstract:

About 10 to 40 % Type 2 diabetes (T2DM) and 30 % Type 1 diabetes (T1DM) suffer from kidney failure, increases huge financial burden for care. Patients with uncontrolled diabetes prone to ESRD, require kidney transplantation, haemodialysis or peritoneal dialysis which adds psychological distress. Present research work. It is prospective study includes 241 subjects conducted at the Department of Biochemistry, D Y Patil University, Navi Mumbai, India. Early detection of Kidney injury evaluated by IL-6, IL-10 CD36 and LDLr gene expressions in T2DM with microalbuminuria by rt-PCR and biochemical parameters by spectrophotometry methods. In study groups all renal parameters and lipids are within normal range except albumin/creatinine ratio (p<.012), e-GFR (p<.00) and cholesterol (p<.00). Descriptive and post hoc test analysis showed high significance (p<.00) for IL-6, IL-10, CD36 and LDLr. Screening biochemical renal parameters are not enough to prevent DN even in microalbuminuria. Early detection of gene expressions of IL-6, IL-10 and CD36, LDLr predict forthcoming risk of kidney injury. Early intervention may prevent morbidity of kidney in type II diabetes associated diabetic nephropathy.


Keywords: Diabetes mellitus, diabetic nephropathy, microalbuminuria, gene expressions.
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How to cite this article:

Khot, V., K.S. Yadav, V.A. Haldankar and Bhutey, A.K. 2017. Vitality of Pro-Inflammatory Cytokine, Scavenger Receptor Proteins and Atherosclerotic Plaque Markers in Risk Prediction of Diabetic Nephropathy.Int.J.Curr.Microbiol.App.Sci. 6(1): 116-124. doi: http://dx.doi.org/10.20546/ijcmas.2017.601.015