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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(4): 2624-2630
DOI: https://doi.org/10.20546/ijcmas.2019.804.306


Vasorelaxant Effect of Heteratisine and 6–O–Benzoyl Heteratisine on Functional Activity of Rat Aorta Smooth Muscle Cells
Bakieva Sh. Muazzam1*, Zaynabiddinov E. Anvar1, Usmanov B. Pulat2 and Esimbetov T. Adilbay3
1Ministry of Higher and Secondary Special Education of the Republic of Uzbekistan,
Namangan State University, Republic of Uzbekistan
2Institute of Biophysics and Biochemistry at the National University of Uzbekistan, Republic of Uzbekistan
3Karakalpak State University named after Berdakh, Republic of Karakalpakstan
*Corresponding author
Abstract:

The effect of geteratisin (3–200 micromol/L) and 6–O–benzoylgeteratisin (10–250 micromol/L) on the contractile activity of the rat aorta smooth muscle cells (SMC) was studied. Isometric tension forces were recorded using a force transducer FT–03 (Grass Instrument Co., USA). In the experiments it was revealed that vasorelaxant effect of heteratisine is mainly associated with the blockade of Ca2+L–channel, receptor–operated Ca2+–channels (ROCC), and store–operated Ca2+–channels (SOCC). Vasorelaxant effect of 6–O–benzoyl heteratisine, which differs from heteratisine with the location of the benzoyl group in C(6)–position, is associated not only with the Ca2+L–channel blockade and SOCC/ROCC and the activation of the NO/cGC/cGMP/PKG cascade reaction.


Keywords: Heteratisine, 6–O–benzoyl heteratisine, Isolated rat aorta, Vasorelaxant effect, Са2+L–channels, NO–synthase, NO/GC/cGMP/ PKG
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How to cite this article:

Bakieva Sh. Muazzam, Zaynabiddinov E. Anvar, Usmanov B. Pulat and Esimbetov T. Adilbay. 2019. Vasorelaxant Effect of Heteratisine and 6–O–Benzoyl Heteratisine on Functional Activity of Rat Aorta Smooth Muscle Cells.Int.J.Curr.Microbiol.App.Sci. 8(4): 2624-2630. doi: https://doi.org/10.20546/ijcmas.2019.804.306