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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
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Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(1): 15-19
DOI: http://dx.doi.org/10.20546/ijcmas.2017.601.002


Age Related Changes in T Cell Subsets in Thymus and Spleen of Layer Chicken (Gallus domesticus)

T.A. Kannan1*, Geetha Ramesh2, S. Ushakumari2, G. Dhinakarraj3 and S. Vairamuthu4

1Centre for Stem Cell Research and Regenerative Medicine Tamil Nadu Veterinary and Animal Sciences University, Madras Veterinary College, Chennai- 600 007, India
2Department of Veterinary Anatomy, Tamil Nadu Veterinary and Animal Sciences University, Madras Veterinary College, Chennai- 600 007, India
3Translational Research Platform - Veterinary Biologicals, Tamil Nadu Veterinary and Animal Sciences University, Chennai- 600 051, India
4Centralised Instrumentation laboratory, Tamil Nadu Veterinary and Animal Sciences University, Madras Veterinary College, Chennai- 600 007, India
*Corresponding author
Abstract:

Flowcytometric analysis of T lymphocyte subset viz., CD and CD8 cells in spleen and thymus was done in Nandanam layer chicken of different age groups ranging from day-old to forty weeks. . In spleen, the mean CD4 and CD8 population was found to be the highest at day one and lowest at twenty weeks of age. However, an increase in both the T cell population was detected at forty weeks.  Among the two cell types studied, CD8 cells were always higher than the CD4 cells, with significant difference (P<0.05) at day one. The distribution pattern of CD4 and CD8 cells in thymus was slightly different from that of spleen. Thymus had more CD4 cells on day one followed with twelve weeks of age. In contrast, CD8 cells were more on twelve weeks followed with day one. The CD4 and CD8 cell populations were lowest in four weeks of age. A distinct difference was observed in the ratio of CD4 and CD8 cells in the spleen and thymus at different age. At day one the ratio was less in spleen and high in the thymus. However, at eight weeks of age, CD4 cell ratio was high in spleen and low in thymus. Nevertheless, the ratio narrowed down at forty weeks of age.


Keywords: T cell subset, Spleen and thymus, Nandanam layer Chicken, Flowcytometric analysis.
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How to cite this article:

Kannan, T.A., Geetha Ramesh, S. Ushakumari, G. Dhinakarraj and Vairamuthu, S. 2017. Age Related Changes in T Cell Subsets in Thymus and Spleen of Layer Chicken (Gallus domesticus).Int.J.Curr.Microbiol.App.Sci. 6(1): 15-19. doi: http://dx.doi.org/10.20546/ijcmas.2017.601.002