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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(4): 1506-1513
DOI: https://doi.org/10.20546/ijcmas.2019.804.176


A Comparative Study of Screening of Hepatitis B by Two Different Immunochromatographic Methods among Patients Attending a Tertiary Care Hospital
Mubashir Nazir, Roomi Yousuf, Muzafar Amin*, Syed Khurshid, Arshi Syed and Talat Masoodi
SKIMS-MC Hospital, Bemina, Srinagar, Jammu and Kashmir, India
*Corresponding author
Abstract:

Hepatitis B is one of the major Global health problems affecting both developing and developed countries. Hepatitis B is caused by Hepatitis B virus which spreads parentally through blood and sexual contact. There are many markers which gives information regarding stages of hepatitis B viral infection. The HBsAg is used for detection and screening of HBV infection. Aim: The study was carried to compare different parameters viz. sensitivity, specificity, positive and negative predictive values of two immunochromatographic Rapid tests with ELISA for HBsAg. Study Design. The study was conducted in Department of Microbiology at SKIMS-MC Hospital for a period of one year. Result: Out of total of 6701 blood samples screened, 19 were positive by ELISA, 17 were positive by Test A (HepaTM Card) and 16 were positive by Test B (Alere Trueline). The sensitivity, specificity, negative and positive predictive value of test A were 89.4%, 100%, 99.9% and 100%. The sensitivity, specificity, negative and positive predictive value of test B were 84.2%, 100%, 99.5% and 100% respectively against ELISA. The Rapid tests (ICT) are not comparable to ELISA in terms of sensitivity but can be used for screening of Hepatitis B in developing countries where resources are limited as rapid tests are cost effective and easy to perform.


Keywords: Hepatitis B, HBsAg, Rapid tests, ICT, ELISA
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How to cite this article:

Mubashir Nazir, Roomi Yousuf, Muzafar Amin, Syed Khurshid, Arshi Syed and Talat Masoodi. 2019. A Comparative Study of Screening of Hepatitis B by Two Different Immunochromatographic Methods among Patients Attending a Tertiary Care Hospital.Int.J.Curr.Microbiol.App.Sci. 8(4): 1506-1513. doi: https://doi.org/10.20546/ijcmas.2019.804.176