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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(4): 2260-2265
DOI: https://doi.org/10.20546/ijcmas.2019.804.264


Hepatoprotective Effect of Aqueous Extract of Gyrocarpus asiaticus on Paracetamol Induced Hepatotoxicity in Zebra Fish
Baisakhi Moharana1*, S.P. Preetha2, C. Balachandran3 and P. Acharya4
1Division of Pharmacology, CSIR-CDRI, Lucknow
2Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, TANUVAS, Chennai, India
3Vice chancellor, TANUVAS, Chennai, India
4Division of Livestock Production and Management, NDRI, Karnal, India
*Corresponding author
Abstract:

Paracetamol induced hepatotoxicity is a common model for accessing the hepatoprotective nature of new molecules. This study was conducted to evaluate the potential of aqueous extract of Gyrocarpus asiaticus on paracetamol induced hepatotoxicity in zebra fish. Fish were challenged with 20mM concentration of paracetamol followed by treatment with aqueous extract of Gyrocarpus asiaticus. Serum was evaluated for alanine transferase (ALT) concentration and liver samples were collected for histopathological analysis. Result of this study showed that, there was marked elevation of ALT in induced group and compare to paracetamol induced toxicity group, Gyrocarpus asiaticus treated group has got marked reduction in ALT which also confirmed through histopathological analysis, where the treatment group showed normal morphological features. Hence further study can be done to elucidate the mechanism of action of Gyrocarpus asiaticus through molecular level to have a confirmation of hepatoprotective nature of this plant.


Keywords: Paracetamol, hepatotoxicity, Gyrocarpus asiaticus, zebra fish, ALT
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How to cite this article:

Baisakhi Moharana, S.P. Preetha, C. Balachandran, Acharya, P. 2019. Hepatoprotective Effect of Aqueous Extract of Gyrocarpus asiaticus on Paracetamol Induced Hepatotoxicity in Zebra Fish.Int.J.Curr.Microbiol.App.Sci. 8(4): 2260-2265. doi: https://doi.org/10.20546/ijcmas.2019.804.264