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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(12): 869-883
DOI: http://dx.doi.org/10.20546/ijcmas.2016.512.095


Therapeutic Potential of Probiotic Lactobacillus plantarum MYS94 against Campylobacter jejuni
K. Poornachandra Rao1, N.K. Hemanth Kumar2 and M.Y. Sreenivasa1*
1Department of Studies in Microbiology, University of Mysore, Manasagangotri,   Mysore, Karnataka, India-570006
2Department of Studies in Botany, University of Mysore, Manasagangotri,   Mysore, Karnataka, India-570006
*Corresponding author
Abstract:

Campylobacter jejuni is one of the most common intestinal pathogen causes of human gastroenterocolitis thereby leading to diarrhea and other serious post-infectious complications. Controlling the C. jejuni infection is critical for reducing campylobacteriosis for a healthy gut. In the current study, Lactobacillus plantarum MYS94 was isolated from traditional fermented wine and characterized for its probiotics properties and therapeutic potential against C. jejuni.The probiotic attributes revealed that, the strain could resist the gut pH, bile salt tolerance, adherence ability to chicken crop epithelial cells, sensitivity to penicillin, amoxicillin, bacitracin and erythromycin, further the strain also exhibited inhibitory potential against common food pathogens. The neutralized cell-free supernatant of Lp MYS94 exhibited 62.04% inhibition of Pseudomonas aeruginosa MTCC 7903 biofilm. The study also evaluated the cholesterol-lowering property of the Lp MYS94 using hen egg yolk as the cholesterol source. The cholesterol in hen egg yolk was assimilated by 62.18% and 31.42% by Lp MYS94and its CFS respectively. In addition, Lp MYS94-CFS tested against C. jejuni by well diffusion and time kill assay revealed a significant effect on C. jejuni with strong inhibitory activity. Collectively, the results suggests that L. plantarum MYS94 could be useful as potential probiotic strain suppressing C. jejuni.


Keywords: Lactobacillus plantarum MYS94,  Gastrointestinal tract,C.jejuni, Probiotics.
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How to cite this article:

Poornachandra Rao, K., N.K. Hemanth Kumar and Sreenivasa, M.Y. 2016. Therapeutic Potential of Probiotic Lactobacillus plantarum MYS94 against Campylobacter jejuni.Int.J.Curr.Microbiol.App.Sci. 5(12): 869-883. doi: http://dx.doi.org/10.20546/ijcmas.2016.512.095