National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Multidrug-resistant bacterial strains are becoming a serious problem. Therefore, the application of natural antimicrobial agents from plant extracts combined with antibiotics to overcome this problem is of major importance. The antimicrobial activity of five plants(geranium, turmeric, thyme, ginger and green tea)methanol extract prepared by ultrasonic-assisted (UAE) combined with antibiotics (amoxicillin, doxycycline, gentamicin and difloxacin) against 16 Staphylococcus aureus chickens isolates was tested using in vitro methods. The interactions between plant extracts and antibiotics are known to be either additive or synergistic or antagonistic. The mean zones of inhibition (mm) and the minimum inhibitory concentration (MIC) of plant extracts and of antibiotics and combination between them was determined. The total phenolic content (TPC) and the antioxidant activity (DPPH) of plant extracts were evaluated. Methanol extracts had high total phenolic compounds which used as a source of natural antioxidants. The results revealed that synergistic effects appear thyme with amoxicillin and gentamicin and difloxacin. Turmeric had synergistic effect with amoxicillin, doxycycline, and difloxacin. Synergistic activity against Gram-positive bacteria demonstrated that extracts could be a source of bioactive substances with a broad spectrum of antibacterial activity especially when combined with antibiotics. In addition, extracts are potential safe sources of bioactive compounds, antioxidants, antibacterial agents which might be applied in different foods and pharmaceutical products.
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