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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(12): 678-686
DOI: http://dx.doi.org/10.20546/ijcmas.2016.512.076


Association of Human GSTM1 and GSTT1 Genes Polymorphisms with Prostate Tumors in Population of the South Provinces of Iraq
Yusra Sebri Abdul Saheb1, Salwa H.N. AL-Rubaiꞌe2, Nahi Y. Yaseen3 and Ahmed Ab. Suleiman4
 1Department of Chemistry, College of Science, Missan University, Missan, Iraq
2Department of Chemistry, College of Science, Al-Mustansiriya University, Baghdad, Iraq
3Department of Heredity, Iraqi Center for Cancer and Medical Genetics research,
Al-Mustansiriya University, Baghdad–Iraq
4College of Science, Al-Anbar University, Al-Anbar, Iraq
*Corresponding author
Abstract:

The second most common type of cancer in men is prostate cancer (PCa). The incidence of PCa may vary among different ethnic groups and countries. The aim of this study is to evaluate the influence of polymorphisms in glutathione–S–transferases M1 and glutathione–S–transferases T1 genes on the risk of developing prostate cancer and benign prostate hyperplasia in a population of south of Iraq. Several polymorphic genes encoding enzymes involved carcinogenesis were studied as possible risk factor of prostate cancer. Genetic polymorphisms in glutathione–S–transferase M1 and glutathione–S–transferase T1 genes were constantly reported as a critical component on prostate cancer risk due to absence of these enzymes possibly contributed. In this study, ninety five men were participated. Fifty five patients with prostate cancer, the mean age 58.42 ± 6.83 years, forty benign prostate hyperplasia mean age 55.17 ± 5.19 years and fifty healthy control mean age 44.10 ± 9.36 years. Results show there is a highly significant difference in Chi-square levels of presents and deletions in glutathione–S–transferases M1 and glutathione–S–transferases T1 genes in all study groups. Also, Significant associations were observed among GSTM1-present + GSTT1-present (p= 0.0496) and GSTM1-null + GSTT1-present (p=0.0136), no significant associations in GSTM1-present + GSTT1-null (p= 0.207) and GSTM1-null + GSTT1-null (p=0.094).


Keywords: Glutathione–S–Transferase, Prostate Cancer, Polymorphism, GSTM1,GSTT1.
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How to cite this article:

Yusra Sebri Abdul Saheb, Salwa H.N. AL-Rubaiꞌe, Nahi Y. Yaseen and Ahmed Ab. Suleiman. 2016. Association of Human GSTM1 and GSTT1 Genes Polymorphisms with Prostate Tumors in Population of the South Provinces of IraqInt.J.Curr.Microbiol.App.Sci. 5(12): 678-686. doi: http://dx.doi.org/10.20546/ijcmas.2016.512.076