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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(3): 1780-1788
DOI: https://doi.org/10.20546/ijcmas.2019.803.208


Haematological Studies of Loranthus bengwensis Ethanolic Leaf Extract on Streptozotocin Induced Diabetic Rats
R.U. Ukpanukpong1*, S.O. Oka2, O.E. Olarinde2, D.I. Basiru2, B.E. Ukwuondi1 and P.O. Aigbadumah3
1Department of Biochemistry, Faculty of Basic Medical Sciences University of Calabar, Nigeria
2Department of Chemical Sciences, Joseph Ayo Babalola University, Ikeji Arakeji. Osun State, Nigeria
3Faculty of Medical Sciences, University of Jos, Nigeria
*Corresponding author
Abstract:

The haematological studies on ethanolic leaf extract of Loranthus Bengwensis were evaluated in streptozotocin induced diabetics albino rats. The phytochemical screening of the ethanolic leaf extract showed the presence of alkaloids, flavonoids, steroids, tannin, saponins, cardiac glycosides, phenolics, terpenoid and quinines. Sixty albino wistar rats were used for the study and at the commencement of the experiment, rats were grouped into six study groups; Non-diabetic Control group, Diabetic Control group, Diabetic rats administered Orthodox drug insulin, Diabetic rats administered 100mg of leaf extract, Diabetic group administered with 200mg of leaf extract; Diabetic group administered with 400mg of leaf extract. There was a drastic reduction in blood glucose level of diabetes treated groups of DLB1, DBL2 and DBL3 at the end of the experiment which portrays the therapeutic efficacy of Loranthus bengwensis ethanolic leaf extract in ameliorating diabetic condition. However, the extract was more efficient at 400mg/kg compared to 100mg/kg and 200mg//kg respectively. This indicates that ethanolic leaf extract of Loranthus bengwensis is relatively more efficient at higher concentration. Other biochemical parameters such as; Haematological; Haemoglobin, Packed Cell Volume, WBC, Platelets Count and Neutrophiles as well as body weight indices were consideration. The results obtained from all these assays as well as the blood glucose assay justify the therapeutic efficacy of Loranthus bengwensis on diabetic condition.


Keywords: Phytochemicals, Body Weight, Haemoglobin, Packed Cell Volume, Platelets, White Blood Cell and Red Blood Cell
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How to cite this article:

Ukpanukpong, R.U., S.O. Oka, O.E. Olarinde, D.I. Basiru, B.E. Ukwuondi and Aigbadumah, P.O. 2019. Haematological Studies of Loranthus bengwensis Ethanolic Leaf Extract on Streptozotocin Induced Diabetic Rats.Int.J.Curr.Microbiol.App.Sci. 8(3): 1780-1788. doi: https://doi.org/10.20546/ijcmas.2019.803.208