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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(3): 1587-1591
DOI: https://doi.org/10.20546/ijcmas.2019.803.184


Anti-ds DNA Levels and C3 and C4 Complement Levels in Suspected Flare Up of Systemic Lupus Erythematosus Patients Attending a Tertiary Care Hospital
Ananthakrishnan Parthasarathy and Meenakshi Subramanian*
Institute of Rheumatology, Madras Medical College, The Tamilnadu Dr. MGR Medical University, Tamilnadu, India
*Corresponding author
Abstract:

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with a variable clinical course and a wide range of organ manifestations. 101 Blood samples were tested for both anti-dsDNA and Complement levels in patients satisfying the 1982 American College of Rheumatology (ACR) criteria (updated in 1997) for SLE with suspected clinical flares using Euroimmun ELISA Anti-ds DNA-NcX ELISA (IgG) kit and by Nephelometry using the Nephstar kit for both the complements C3 and C4. In majority of patients Anti ds DNA, C3 and C4 levels were normal and almost same number of patients had Anti ds DNA, C3 were increased with decreased C4 levels. The high index of clinical suspicion and concurrent laboratory estimation of Anti ds DNA, C3 and C4 levels will help the clinician in the diagnosis and initiation of proper treatment of SLE and its flare ups.


Keywords: Systemic lupus erythematosus (SLE)
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How to cite this article:

Ananthakrishnan Parthasarathy and Meenakshi Subramanian. 2019. Anti-ds DNA Levels and C3 and C4 Complement Levels in Suspected Flare Up of Systemic Lupus Erythematosus Patients Attending a Tertiary Care Hospital.Int.J.Curr.Microbiol.App.Sci. 8(3): 1587-1591. doi: https://doi.org/10.20546/ijcmas.2019.803.184