National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Diabetes mellitus is the most prevalent metabolic syndrome characterized by hyperglycemia due to relative deficiency of insulin. This metabolic disorder caused by multiple etiologies characterized by absolute or relative deficiency of insulin secretion with or without varying degree of insulin resistance. Sedentary life style, stress and obesity are two major epidemiological determinants of diabetes mellitus. There has been a tremendous interest in the development of alternative medicine for diabetes. The goal of the present study was to provide in vitro evidence for potential inhibition of in vitro antioxidant and antidiabetic activity of aqueous extract of black cumin, garlic, fenugreek individual and its combination at different doses in STZ-NT-induced diabetic rats. Diabetic rats were treated with aqueous extract for 60 days. The degree of protection was evaluated using biochemical parameters such as lipid peroxidation levels and superoxide dismutase (SOD).These extract significantly (p<0.05) lowered the elevated fasting blood glucose, oxidative parameters but no effect seen in haematological indices. This oxidative stress was related to increase lipid peroxidation level and decreased superoxide dismutase activity in diabetic rats. We suggested that black cumin, garlic, fenugreek and its combination could be a protective effect and used as antidiabetic complement in case of Type II diabetes mellitus.
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