Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2019) [Effective from January 1, 2019]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(3): 1219-1227
DOI: https://doi.org/10.20546/ijcmas.2019.803.144


Antioxidative Potential of Spices in Experimentally Induced Type-II Diabetes in Rats
T.J. Sheikh1*, D.V. Joshi2, B.J. Patel2 and Rajeev Ranjan3
1Department of Veterinary Pathology, College of Veterinary Science & A.H., Rewa, Madhya Pradesh, India
2Department of Veterinary Pathology, College of Veterinary Science and A.H., Sardarkrushinagar, Gujarat, India
3Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science & A.H., Rewa, Madhya Pradesh, India
*Corresponding author
Abstract:

Diabetes mellitus is the most prevalent metabolic syndrome characterized by hyperglycemia due to relative deficiency of insulin. This metabolic disorder caused by multiple etiologies characterized by absolute or relative deficiency of insulin secretion with or without varying degree of insulin resistance. Sedentary life style, stress and obesity are two major epidemiological determinants of diabetes mellitus. There has been a tremendous interest in the development of alternative medicine for diabetes. The goal of the present study was to provide in vitro evidence for potential inhibition of in vitro antioxidant and antidiabetic activity of aqueous extract of black cumin, garlic, fenugreek individual and its combination at different doses in STZ-NT-induced diabetic rats. Diabetic rats were treated with aqueous extract for 60 days. The degree of protection was evaluated using biochemical parameters such as lipid peroxidation levels and superoxide dismutase (SOD).These extract significantly (p<0.05) lowered the elevated fasting blood glucose, oxidative parameters but no effect seen in haematological indices. This oxidative stress was related to increase lipid peroxidation level and decreased superoxide dismutase activity in diabetic rats. We suggested that black cumin, garlic, fenugreek and its combination could be a protective effect and used as antidiabetic complement in case of Type II diabetes mellitus.


Keywords: Black cumin, Garlic, Fenugreek, Diabetes Mellitus, Lipid Peroxidation, SOD and STZ-NT
Download this article as Download

How to cite this article:

Sheikh, T.J., D.V. Joshi, B.J. Patel and Rajeev Ranjan. 2019. Antioxidative Potential of Spices in Experimentally Induced Type-II Diabetes in Rats.Int.J.Curr.Microbiol.App.Sci. 8(3): 1219-1227. doi: https://doi.org/10.20546/ijcmas.2019.803.144