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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(3): 851-860
DOI: https://doi.org/10.20546/ijcmas.2019.803.102


Effect of Epigenetic Modifiers on Fermentation Parameters of Endophytic Fungi from Plants Growing in Uzbekistan
T.G. Gulyamova, L.I. Abdulmyanova, D.M. Ruzieva, G.A. Rasulova, U.K. Yusupov and R.S. Sattarova*
Department of Biochemistry and Biotechnology of Physiologically Active Compounds, Institute of Microbiology of the Academy of Sciences RU, Uzbekistan
*Corresponding author
Abstract:

The present study aimed to investigate the effects of addition of epigenetic modifiers in the growth medium on biomass and secondary metabolites production in the suspension cultures of the endophytes Thielavia microspora MO46L with antimicrobial activity, isolated from Melissa officinalis, Penicillium concavoradulozum VE89L and Aspergillus amstelodami VR177L isolated from Vinca plants, both producing vinblastine and vincristine. The obtained data showed that quercetin and nicotinamide affected the physiological and cultural properties of studied endophytic strains as well as their metabolic profile. Results of this study also showed that quercetin can be used to induce the synthesis of vinblastine as target product in the endophytic fungi P. concavoradulozum VE89L and A. amstelodami VR177L.


Keywords: Endophytic fungi, secondary metabolites, epigenetic modifiers, nicotinamide, quercetin
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How to cite this article:

Gulyamova, T.G., L.I. Abdulmyanova, D.M. Ruzieva, G.A. Rasulova, U.K. Yusupov and Sattarova, R.S. 2019. Effect of Epigenetic Modifiers on Fermentation Parameters of Endophytic Fungi from Plants Growing in Uzbekistan.Int.J.Curr.Microbiol.App.Sci. 8(3): 851-860. doi: https://doi.org/10.20546/ijcmas.2019.803.102