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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(3): 251-262
DOI: https://doi.org/10.20546/ijcmas.2019.803.032


Study of Epstein Barr virus, Human Herpes 6 and Human Herpes 7 in Children with Acute Lymphoblastic Leukemia
Mohamed Anies Rizk1* and Ahmad Darwish2
1Clinical Pathology Department, Mansoura Faculty of Medicine, Egypt
2Pediatric Department, Mansoura Faculty of Medicine, Egypt
*Corresponding author
Abstract:

The aim of the present study is to identify the presence of Epestein Barr virus (EBV), Human Herpes virus 6 (HHV6)and Human Herpes virus 7 (HHV7) by molecular methods in newly diagnosed ALL in children and to correlate their presence with clinical and immunophenotypes of ALL. The present study included 60 children at the time of diagnosis of ALL before start of the therapy and 60 healthy cross match age and sex children as a control group. The study of EBV, HHC6 and HHV7 was carried out by real time polymerase chain reaction (PCR). In comparison between the prevalence of EBV, HHV6, HHV7 between patients and control there was statistically significant increase in prevalence rates (31.7 versus 1.7 for EBV, 16.7% versus 3.3% for HHV6 and 13.3% versus 8.3% for HHV7 respectively, P=0.0001). Moreover, the mean± SD copies/ml was statistically significant higher for HHV6 in patients compared to the controls (P=0.0001). There was significant association between EBV and HHV6 infection in patients (P=0.001). In EBV+ ALL, there was significant higher rates of hepatosplenomegaly (47.4%, P=0.01) In conclusion, EBV, HHV6 and HHV7 viruses were present in high rates in ALL which suggest a role for these viruses in pathogenesis of ALL. Further studies are required to validate this hypothesis.


Keywords: ALL, EBV, HHV6, HHV7, Real time PCR
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How to cite this article:

Mohamed AniesRizk and Ahmad Darwish. 2019. Study of Epstein Barr virus, Human Herpes 6 and Human Herpes 7 in Children with Acute Lymphoblastic leukemia.Int.J.Curr.Microbiol.App.Sci. 8(3): 251-262. doi: https://doi.org/10.20546/ijcmas.2019.803.032