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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(2): 1783-1791
DOI: https://doi.org/10.20546/ijcmas.2019.802.210


Sustained Transdermal Release of Lignans Facilitated by Sophorolipid based Transferosomal Hydrogel for Cosmetic Application
N. Jayarama Naik2, Isha Abhyankar1, Priti Darne1, Asmita Prabhune1 and Basavaraj Madhusudhan2*
1Division of Biochemical Sciences, National Chemical Laboratory, Pune, India
2Department of Food Technology, Davangere University, Davangere, Karnataka, India
*Corresponding author
Abstract:

The current study focuses on designing biodegradable transferosomal hydrogel using lignans and bio surfactant for transdermal applications. In the study, the lignans concentrate (LC) was extracted from flaxseeds and used to prepare vesicular transferosomes/transferosomal hydrogel by thin film hydration technique for drug delivery. The resultant formulations were characterized using light microscopy, DLS, Zeta potential, entrapment efficiency (EE %) and stability. In vitro skin permeation studies were also performed. The synthesized transferosomes were spherical in shape. The entrapment efficiency (%EE) of transferosomes with synthetic surfactant (SST) was 38.54% while the efficiency obtained by bio-surfactant transferosomes (BST) was 45.87%. Upon optimization, BST exhibited improved %EE (75.81 %). The particle sizes, zeta potential and PDI of BST were 213.4 nm, -30.6 mV, 0.316 and of SST210.5 nm, −23.62 mV, 0.349, respectively. The transferosomes follow Higuchi model whereas transferosomes hydrogel follow the First order kinetics. The transferosomes were stable over a month at 4°C and exhibited similar transdermal permeation as fresh samples. The Hydrophile-Lipophile Balance (HLB) of SPL was in the order of 13 to 15making BST a better alternative to synthetic surfactants. Thus it can be concluded that the transferosomal hydrogels infused with sophorolipid could be used as carriers of LC with promising permeation characteristics for transdermal and cosmetic applications.


Keywords: Biodegradable, Bio-surfactant, Flaxseed, Lignans, Transferosomal hydrogel
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How to cite this article:

Jayarama Naik, N., Isha Abhyankar, Priti Darne, Asmita Prabhune and Basavaraj Madhusudhan. 2019. Sustained Transdermal Release of Lignans Facilitated by Sophorolipid based Transferosomal Hydrogel for Cosmetic Application.Int.J.Curr.Microbiol.App.Sci. 8(2): 1783-1791. doi: https://doi.org/10.20546/ijcmas.2019.802.210