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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(2): 760-775
DOI: https://doi.org/10.20546/ijcmas.2019.802.088


Toxocariasis and Toxoplasmosis in Children with Idiopathic Epilepsy in Mid-Region of the Nile Delta, Egypt: Prevalence and Risk Factors
Amina M. Salama1*, Ahmed A. Daoud1, Azza K. Elshehawy2, Ahmad A. Othman1, Mohamed M. Eid1
1Department of Medical Parasitology
2Department of Pediatrics, Faculty of Medicine, Tanta University, Egypt
*Corresponding author
Abstract:

Epilepsy is one of the most common and important neurological disorders among children especially in developing countries. Toxoplasma gondii (T. gondii) is an intracellular protozoan capable of forming cysts in the brain of chronically infected humans. Moreover, the larvae of Toxocara canis (T. canis) can locate in the central nervous system leading to several neurological disorders. This study was undertaken to identify the prevalence and risk factors of toxocariasis and toxoplasmosis in children with idiopathic epilepsy. This study was conducted on 150 children aged 2−15 years, including 100 children suffering from idiopathic epilepsy and 50 apparently healthy children as a control group. All children were submitted to clinical questionnaire. They were tested for the presence of anti-Toxocara IgG by ELISA and western blotting, and for presence of anti-Toxoplasma IgG and IgM by ELISA and avidity test. The frequency of Toxocara infection in epileptic patients was 13% versus 4% of the healthy group by ELISA. By western blotting technique, Anti-Toxocara IgG antibodies were detected in 7 (53.8%) of ELISA positive children in epileptic children group, whereas the serum samples of all ELISA-positive normal children were negative. Contact with dogs is the main risk factors for toxocariasis. Regarding T. gondii, by ELISA, 74 (74%) epileptic children had anti-T. gondii antibody, 59 had Toxoplasma IgG only, 3 cases had Toxoplasma IgM only, and 12 cases had both Toxoplasma IgG and IgM. Moreover, 20 (40%) normal children had positive results. Residence, contact with cats, contact with soil, and drinking unfiltered water are important risk factors for toxoplasmosis. There was significant association between toxoplasmosis and idiopathic epilepsy. Despite being statistically insignificant, the association between Toxocara infection and epilepsy still needs further investigation.


Keywords: Toxocara canis, Toxoplasma gondii, epilepsy, ELISA, Western blotting
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How to cite this article:

Amina M. Salama, Ahmed A. Daoud, Azza K. Elshehawy, Ahmad A. Othman, Mohamed M. Eid. 2019. Toxocariasis and Toxoplasmosis in Children with Idiopathic Epilepsy in Mid-Region of the Nile Delta, Egypt: Prevalence and Risk Factors.Int.J.Curr.Microbiol.App.Sci. 8(2): 760-775. doi: https://doi.org/10.20546/ijcmas.2019.802.088