National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The activation of Toll-like receptor 4 (TLR4) may be an important event in the immune evasion of tumor cells. TLR4 polymorphisms in breast cancer patients have recently attracted great interest. However, there has been little research on the association between the TLR4 +3725G/C polymorphism and the risk of breast cancer. This study aimed to investigate the frequency of TLR4 +3725G/C gene polymorphism in Egyptian breast cancer patients in order to evaluate its prognostic role in this malignancy. This study was conducted on 75 newly diagnosed breast cancer female patients and 25 apparently healthy control females. Genotyping of TLR4 +3725G/C polymorphism was performed by PCR/RFLP. The present study revealed that the frequencies of GC and CC genotypes of TLR4 +3725G/C polymorphism (P = 0.018) and TLR4 +3725C allele frequency (P=0.003) were significantly higher in breast cancer cases than controls. Furthermore, there was a statistically significant relation between TLR4 +3725GC, CC genotypes and tumor size, LN infilteration, ER and PR status in BC patients (P<0.001). Our results suggested that TLR4 +3725G/C polymorphism might be associated with increased susceptibility to breast cancer in Egyptian women and could be used as a prognostic marker for this malignancy.
Citations |
 |
 |
 |
 |
