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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(1): 2429-2437
DOI: https://doi.org/10.20546/ijcmas.2019.801.256


Association of Toll-like Receptor 4 +3725G/C Polymorphism in Egyptian Breast Cancer Patients
Yosra Zamzam1*, Hesham Elsorogy1, Gihan Attia1 and Mohamed Al-Mahalawy2
1Department of Clinical Pathology, 2Department of General Surgery, Faculty of Medicine, Tanta University, Egypt
*Corresponding author
Abstract:

The activation of Toll-like receptor 4 (TLR4) may be an important event in the immune evasion of tumor cells. TLR4 polymorphisms in breast cancer patients have recently attracted great interest. However, there has been little research on the association between the TLR4 +3725G/C polymorphism and the risk of breast cancer. This study aimed to investigate the frequency of TLR4 +3725G/C gene polymorphism in Egyptian breast cancer patients in order to evaluate its prognostic role in this malignancy. This study was conducted on 75 newly diagnosed breast cancer female patients and 25 apparently healthy control females. Genotyping of TLR4 +3725G/C polymorphism was performed by PCR/RFLP. The present study revealed that the frequencies of GC and CC genotypes of TLR4 +3725G/C polymorphism (P = 0.018) and TLR4 +3725C allele frequency (P=0.003) were significantly higher in breast cancer cases than controls. Furthermore, there was a statistically significant relation between TLR4 +3725GC, CC genotypes and tumor size, LN infilteration, ER and PR status in BC patients (P<0.001). Our results suggested that TLR4 +3725G/C polymorphism might be associated with increased susceptibility to breast cancer in Egyptian women and could be used as a prognostic marker for this malignancy.


Keywords: Toll like receptor 4, +3725G/C polymorphism, Breast cancer, Prognosis
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How to cite this article:

Yosra Zamzam, Hesham Elsorogy, Gihan Attia and Mohamed Al-Mahalawy. 2019. Association of Toll-like Receptor 4 +3725G/C Polymorphism in Egyptian Breast Cancer Patients.Int.J.Curr.Microbiol.App.Sci. 8(1): 2429-2437. doi: https://doi.org/10.20546/ijcmas.2019.801.256