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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2016 - IJCMAS--ICV 2016: 92.3 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2016: 92.3
Index Copernicus ICI Journals Master List 2016 - IJCMAS--ICV 2016: 92.3
For more details click here
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(12): 11-17
DOI: http://dx.doi.org/10.20546/ijcmas.2016.512.002


Assessment of Serum Interleukin-33 Level in Psoriatic Patients
Abdel Aziz I. El-Taweel1, Fatma M. El-Sawy1, Omaima A. El Sayed2*
and Nessma G.Z. Amin1
1Dermatology and Andrology, Faculty of Medicine, Benha University, Egypt
2Microbiology and Immunology Department, Mansoura University, Egypt
*Corresponding author
Abstract:

Psoriasis is a common chronic inflammatory skin disease affecting up to 2–3% of the population worldwide. Interleukin-33 is a recently discovered cytokine and one of the newest members that belongs to the IL-1 super-family inflammatory cytokines and is mainly expressed by different types of structural cells. IL-33 is considered an alarm molecule due to its release after necrosis or tissue damage.  Psoriasis is associated with chronic inflammation and it often coexists with inflammatory arthritis in which IL-33 has been implicated. Assessment of serum IL-33 levels in psoriatic patients of different types and invistigate its correlation to the severity and extent of psoriasis.It is a case-control study, serum IL-33 levels were assessed by using commercial enzyme-linked immunosorbent assay kits (ELISA) in 40 psoriatic patients of different types (group I) and 30 apparaently healthy subjects as control (group II) with matched age and sex. A significant difference in IL-33 serum levels between patients and control was detected. Also positive correlation between IL-33 and Psoraisis Area and Sevirity Index (PASI) was detected. IL-33 could be considered as a reliable marker among different types of psoriasis and disease severity.


Keywords: Psoriasis,enzyme-linked immunosorbent assay, interleukin 33.
 
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How to cite this article:

Abdel Aziz I. El-Taweel, Fatma M. El-Sawy, Omaima A. El Sayed and Nessma G.Z. Amin. 2016. Assessment of Serum Interleukin-33 Level in Psoriatic Patients.Int.J.Curr.Microbiol.App.Sci. 5(12): 11-17. doi: http://dx.doi.org/10.20546/ijcmas.2016.512.002