National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Dengue shock syndrome is a severe complication of Dengue Hemorrhagic Fever (DHF), characterized by a massive increase in vascular permeability. This prospective study was conducted to assess the pathophysiologic and prognostic role of proinflammatory and regulatory cytokines in the inpatient population tested positive for Dengue fever by using commercially prepared ELISA kits for IL-10. A total of 100 blood samples for this study were collected from pediatric patients and adult patients. The patients were tested for NS1 antigen of DENV and IgM antibodies against DENV. The levels of Positive cases were then selected for the study as per their platelet count. IL 10 was obtained using ELISA and statistically analyzed and results were interpreted. All the patients included in the study had a platelet count of less than 1,00,000/cu.mm. minimum count being 16000 and a maximum of 1,00,000 with a mean value of 63,000. One third of the Dengue positive patients had very high levels of IL-10 level. Interleukin 10 values and clinical features were analyzed using Pearson’s Chi Square Test and the Significance was calculated. There was a significant association (p=0.025) between the IL categorization and the clinical features i.e. patients with Severe Dengue or Dengue with danger signs had significantly higher number of IL-10 levels. Early diagnosis and interventional measures can play a vital role in Dengue prognosis and can also prevent the patient from landing into Dengue Hemorrhagic Fever or Dengue Shock Syndrome. The present study clearly indicates that IL10 is a highly sensitive marker of Severe Dengue and can be used as a screening tool in Secondary Dengue patients or those with warning signs.
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