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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(1): 1779-1787
DOI: https://doi.org/10.20546/ijcmas.2019.801.189


Pathophysiologic and Prognostic Role of IL-10 as a Proinflammatory and Regulatory Cytokine in Dengue Fever
Saishruti1G. Sucila Thangam2* and Revathy1
1Department of Microbiology, Tirunelveli Medical College, Tirunelveli - 627 011, Tamil Nadu, India
2Department of Microbiology, Government Theni Medical College, Theni - 625 512,
Tamil Nadu, India
*Corresponding author
Abstract:

Dengue shock syndrome is a severe complication of Dengue Hemorrhagic Fever (DHF), characterized by a massive increase in vascular permeability. This prospective study was conducted to assess the pathophysiologic and prognostic role of proinflammatory and regulatory cytokines in the inpatient population tested positive for Dengue fever by using commercially prepared ELISA kits for IL-10. A total of 100 blood samples for this study were collected from pediatric patients and adult patients. The patients were tested for NS1 antigen of DENV and IgM antibodies against DENV. The levels of Positive cases were then selected for the study as per their platelet count. IL 10 was obtained using ELISA and statistically analyzed and results were interpreted. All the patients included in the study had a platelet count of less than 1,00,000/cu.mm. minimum count being 16000 and a maximum of 1,00,000 with a mean value of 63,000. One third of the Dengue positive patients had very high levels of IL-10 level. Interleukin 10 values and clinical features were analyzed using Pearson’s Chi Square Test and the Significance was calculated. There was a significant association (p=0.025) between the IL categorization and the clinical features i.e. patients with Severe Dengue or Dengue with danger signs had significantly higher number of IL-10 levels. Early diagnosis and interventional measures can play a vital role in Dengue prognosis and can also prevent the patient from landing into Dengue Hemorrhagic Fever or Dengue Shock Syndrome. The present study clearly indicates that IL10 is a highly sensitive marker of Severe Dengue and can be used as a screening tool in Secondary Dengue patients or those with warning signs.


Keywords: Dengue shock syndrome, Dengue Hemorrhagic Fever, ELISA, Platelet count, IL-10
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How to cite this article:

Saishruti, G. Sucila Thangam and Revathy. 2019. Pathophysiologic and Prognostic Role of IL-10 as a Proinflammatory and Regulatory Cytokine in Dengue Fever.Int.J.Curr.Microbiol.App.Sci. 8(1): 1779-1787. doi: https://doi.org/10.20546/ijcmas.2019.801.189