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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(1): 1307-1313
DOI: https://doi.org/10.20546/ijcmas.2019.801.139


Co-Circulation of Dengue Serotypes in a Tertiary Care Hospital in NCR Region
R. Tomar, D. Bisht* and V. Goel
Department of Microbiology, Santosh Medical College & Hospital, Ghaziabad, Uttar Pradesh, India
*Corresponding author
Abstract:

Dengue is the most important and rapidly spreading mosquito-borne viral disease in the world. It is caused by any of the 4 serologically related virus serotypes designated as: DEN-1, DEN-2, DEN-3 and DEN-4, each causing its characteristic symptoms which range from acute febrile illness to severe manifestations (DHF and DHS). The present study focuses on the circulating serotypes of Dengue in this region. A total of 246 clinically suspected patients of Dengue fulfilling the WHO case definition were undertaken in the study. Acute phase blood samples were collected, centrifuged and tested for NS1 antigen, IgM and IgG antibody and samples positive by one of the parameters: NS1 Ag and/or IgM Ab/IgG Ab were further subjected to Real time RT-PCR. Of the 246 clinically suspected cases of Dengue, 68 (27.6%) were positive for NS1 Ag and/or IgM Ab/IgG Ab and of these, 30 (44%) samples were positive by Real time RT-PCR. All the 4 Dengue serotypes were found to co-circulate in this region of which, 22 cases (73.33%) were positive for DEN-3, 4 cases (13.33.%) were positive for DEN-1, 3 cases (10%) were positive for DEN-4 and 1 case (3.33%) was positive for DEN-2 respectively. The study highlights the co-circulation of all the 4 dengue serotypes with DEN-3 being the predominant serotype. The present investigation will not only help us to determine the evolutionary pattern of emerging Dengue virus but also assist us in forecasting dengue outbreaks and improving control measures of vectors thus helping us to prevent future outbreaks.


Keywords: Dengue serotypes, NS1 Ag, DEN-3, Outbreaks
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How to cite this article:

Tomar, R., D. Bisht and Goel, V. 2019. Co-Circulation of Dengue Serotypes in a Tertiary Care Hospital in NCR Region.Int.J.Curr.Microbiol.App.Sci. 8(1): 1307-1313. doi: https://doi.org/10.20546/ijcmas.2019.801.139