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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(11): 795-810
DOI: http://dx.doi.org/10.20546/ijcmas.2016.511.091


Diabetes Mellitus and its Control by Ocimum sanctum Extract in Mice Diabetic Model
Utsav1, Baidyanath Kumar2* and Atul Kumar3
1Research scholar, Department of Biotechnology, Maharishi Markendeshwar University, Mullana, Ambala (Haryana), India
2Visiting Professor, Department of Biotechnology, Patna Science College, Patna (Bihar), India
3Research Scholar, Department of Biotechnology, College of Commerce (MU), Patna, India
*Corresponding author
Abstract:

Diabetes mellitus is the most prevalent metabolic syndrome world- wide and is characterized by hyperglycemia resulting in various short- term metabolic changes in lipid and protein metabolism and long- term irreversible vascular changes which include diabetic- specific complications viz., retinopathy, nephropathy and neuropathy. Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies characterized by absolute or relative deficiency of insulin secretion with or without varying degree of insulin resistance. Sedentary life style and obesity are two major epidemiological determinants of diabetes mellitus. In the present investigation hypoglycemic efficacy of Ocimum sanctum methanol extract was tested on STZ induced mice diabetic models. The results clearly indicated that the diabetic control (DC) mice presented a significant lowering of body weight (p<0.001) when compared with the normal control (NC) mice. The DC mice showed a significantly (p<0.001) higher level of glucose (+279%), when compared with their normal control counterparts. Diabetic mice of both of the groups (DT150 and DT250) showed a reduction in glucose levels, when compared to the DC ones. The results clearly indicated that the O. sanctum whole plant methanol extract is antidiabetic in nature due to the presence of different types of active phytochemicals.


Keywords: Diabetes mellitus, Ocimum sanctum, Streptozotocin,Antidiabetic,Mice.
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How to cite this article:

Utsav, Baidyanath Kumar and Atul Kumar. 2016. Diabetes Mellitus and its Control by Ocimum sanctum Extract in Mice Diabetic Model.Int.J.Curr.Microbiol.App.Sci. 5(11): 795-810. doi: http://dx.doi.org/10.20546/ijcmas.2016.511.091