National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Cefquinome is fourth generation cephalosporin developed exclusively for veterinary use. The present research was aimed to investigate the disposition kinetic profile of cefquinome at the dose level of 2 mg.kg-1 body weight following single intramuscular administration. Cefquinome concentrations in plasma were determined by microbiological assay technique using Kocuria rhizophila MTCC 1541 as the test organism. The plasma concentration–time profile following intramuscular administration was best described by one-compartment open model. The peak plasma concentration (Cmax) of 5.79 ± 0.35 μg.ml-1 was achieved at 1.10 ± 0.17 h (tmax). The absorption half-life (t½ka), elimination half-life (t½β), area under plasma drug concentration-time curve (AUC) and apparent volume of distribution (Vdarea) of cefquinome were 0.25 ± 0.04 h, 1.68 ± 0.16 h, 16.02 ± 1.11 μg.ml-1.h and 0.30 ± 0.03 L.kg-1, respectively. Cefquinome @ 2 mg.kg-1 at 12 hour dosing interval is sufficient to maintain desired therapeutic level in calves considering MIC ≤ 0.25 μg.ml-1.
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