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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(1): 494-500
DOI: https://doi.org/10.20546/ijcmas.2019.801.053


Disposition Kinetics of Cefquinome in Calves after a Single Intramuscular Bolus Dose
Hemvati, Pratishtha Sharma* and Ashok Gaur
Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Science, Rajasthan University of Veterinary and Animal Sciences (RAJUVAS), Bikaner-334001, Rajasthan, India
*Corresponding author
Abstract:

Cefquinome is fourth generation cephalosporin developed exclusively for veterinary use. The present research was aimed to investigate the disposition kinetic profile of cefquinome at the dose level of 2 mg.kg-1 body weight following single intramuscular administration. Cefquinome concentrations in plasma were determined by microbiological assay technique using Kocuria rhizophila MTCC 1541 as the test organism. The plasma concentration–time profile following intramuscular administration was best described by one-compartment open model. The peak plasma concentration (Cmax) of 5.79 ± 0.35 μg.ml-1 was achieved at 1.10 ± 0.17 h (tmax). The absorption half-life (t½ka), elimination half-life (t½β), area under plasma drug concentration-time curve (AUC) and apparent volume of distribution (Vdarea) of cefquinome were 0.25 ± 0.04 h, 1.68 ± 0.16 h, 16.02 ± 1.11 μg.ml-1.h and 0.30 ± 0.03 L.kg-1, respectively. Cefquinome @ 2 mg.kg-1 at 12 hour dosing interval is sufficient to maintain desired therapeutic level in calves considering MIC ≤ 0.25 μg.ml-1.


Keywords: Calves, Cefquinome, Pharmacokinetics
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How to cite this article:

Hemvati, Pratishtha Sharma and Ashok Gaur. 2019. Disposition Kinetics of Cefquinome in Calves after a Single Intramuscular Bolus Dose.Int.J.Curr.Microbiol.App.Sci. 8(1): 494-500. doi: https://doi.org/10.20546/ijcmas.2019.801.053