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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(1): 261-270
DOI: https://doi.org/10.20546/ijcmas.2019.801.029


In silico Approaches for the Ecdysone Receptor of Hemiptera: The First Step for Rational Pesticide Discovery
Ciro Pedro Guidotti Pinto*
School of Agricultural and Veterinarian Sciences, São Paulo State University (UNESP), Access by Av. Dr. Castellane, S/N, Jaboticabal, São Paulo, Brazil
*Corresponding author
Abstract:

Ecdysteroids are hormones with an important role in the molting, reproduction and immunological defense of arthropods. Ecdysone Receptor (EcR) is a protein that belongs to the superfamily of nuclear receptors, widely studied for pesticide discovery. Currently, several non-steroidal molecules, belonging to the chemical group of diacilhydrazines (DAH), are commercially available for pest control. Such molecules are specific for lepidopteran or coleopteran pests. Hemipterans are important pests in most crops and many cases of pesticide resistance are reported. There is no pesticides targeting hemipteran EcR and such strategy would be interesting in the point of view of controlling sucker insects. In this context, this work aimed to explore hemipterans EcR for in silico study for rational pesticide design. Amino acid residues of binding site are mostly conserved among different insect orders, which explains the unspecificity of ecdysteroids, such as 20-hydroxyecdysone or Ponasterone-A. Hemipteran EcR presents several cavities around the binding pocket. Those cavities can be explored as a target for allosteric modulators/inhibitors. Further, conserved amino acids in hemipteran EcR binding pocket are interesting targets for pharmacophore-based pesticide discovery. Analysis of specific characteristics of hemipteran EcR is the first step for novel and selective pesticide discovery.


Keywords: 20-hydroxyecdysone, Ponasterone-A, Binding site, Sucker insects, Pharmacophore, Ecdysis
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How to cite this article:

Ciro Pedro Guidotti Pinto. 2019. In silico Approaches for the Ecdysone Receptor of Hemiptera: The First Step for Rational Pesticide Discovery.Int.J.Curr.Microbiol.App.Sci. 8(1): 261-270. doi: https://doi.org/10.20546/ijcmas.2019.801.029