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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(12): 3203-3208
DOI: https://doi.org/10.20546/ijcmas.2018.712.370


Peculiarities of Sputum Microbiocenosis among Occupational COPD Patients with Different Clinical Phenotypes and Comorbidities
Vasily D. Fedotov1,2*, Natalya V. Mokeeva1, Irina S. Dobrotina2, Anastasia N. Novikova2, Viktoria E. Kovalenko2 and Aleksandra A. Kalınına2
1Federal Budget Scientific Institution, Hygiene and Occupational Pathology Research Institute of Nizhny Novgorod, Federal Service for the Oversight of Consumer Protection and Welfare, Russian Federation
2Federal State Budgetary Educational Institution of Higher Education, Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation
*Corresponding author
Abstract:

The aim of the research was to study the microbial landscape of sputum of patients with occupational COPD with different clinical phenotypes and comorbidity. The objective of the study was 374 patients with chronic occupational respiratory pathology. A comparative analysis of sputum microbiocenosis was performed in all the patients of the groups (on the whole, there were 616 samples of sputum gathered from 374 patients). Microorganisms could be detected statistically more often in patients with the combination of COPD and DM (p<0.001). A bacterial monoculture statistically more often was detected in patients with chronic non obstructive bronchitis and COPD – non exacebrator groups (p<0.001). Microbial associations were detected significantly more often among the patients who had COPD-Asthma overlap and DM II (p<0.001). The conspicuous quantitative and qualitative changes of respiratory tract microbiom of patients with occupational COPD are observed only if they have associated DM II.


Keywords: Occupational COPD, Microbiom, Chronic bronchitis, Diabetes mellitus
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How to cite this article:

Vasily D. Fedotov, Natalya V. Mokeeva, Irina S. Dobrotina, Anastasia N. Novikova, Viktoria E. Kovalenko and Aleksandra A. Kalınına. 2018. Peculiarities of Sputum Microbiocenosis among Occupational COPD Patients with Different Clinical Phenotypes and Comorbidities.Int.J.Curr.Microbiol.App.Sci. 7(12): 3203-3208. doi: https://doi.org/10.20546/ijcmas.2018.712.370