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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(12): 2786-2793
DOI: https://doi.org/10.20546/ijcmas.2018.712.316


Anti-cancerous Activities of Anthocyanins of Banana cv. Nendran (Musa sp.) Flower Bracts against Human Colon and Cervical Cancer Cell Lines

Suman1, K. Kalaimathi1, S. Palanichamy2, R. Sowmiya2,Mayil Vaganan2*, I. Ravi2 and S. Uma2

1Dr. N.G.P. Arts and Science College, Kalapatty, Coimbatore, Tamil Nadu, India
2ICAR-National Research Centre for Banana, Thogamalai Road, Thayanur Post, Tiruchirappalli, Tamil Nadu, India
*Corresponding author
Abstract:

A comparative study on the anticancer effects of anthocyanins derived from banana cv. Nendran flower bracts against human colon (HT-29) and cervical cancer (HeLa) cells were investigated. In vitro assays by MTT, AO/EtBr and MMP revealed that anthocyanins extract inhibited the growth of both HT-29 and HeLa cells. The percentage of cell viability decreased linearly with increment of anthocyanins. The IC50 values for anthocyanins were 41.18 µg/ml for colon cancer cells and 46.50 µg/ml for the cervical cancer cells by MTT assay. The MMP assay indicated IC50 values of 71.18 and 106.5 µg/ml respectively for HT-29 cells and HeLa cells. The study demonstrates that anthocyanins of banana flower bracts are potential anti-cancerous compounds.


Keywords: Banana bracts, Anthocyanins, Colorectal cancer, Cervical cancer, MTT assay
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How to cite this article:

Suman, R., K. Kalaimathi, R. Suman, S. Palanichamy, R. Sowmiya, M. Mayil Vaganan, I. Ravi and Uma, S. 2018. Anti-cancerous Activities of Anthocyanins of Banana cv. Nendran (Musa sp.) Flower Bracts against Human Colon and Cervical Cancer Cell Lines.Int.J.Curr.Microbiol.App.Sci. 7(12): 2786-2793. doi: https://doi.org/10.20546/ijcmas.2018.712.316