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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(12): 740-745
DOI: https://doi.org/10.20546/ijcmas.2018.712.091


Study of Kidney Function Tests in Pre and Post-treated Dogs on Chemotherapy with Doxorubicin and Vincristine in Venereal Granuloma
Anup Yadav1, Praveen Kumar2*, Lokesh3, Ashwani Kumar2, Pankaj Kumar4, Rajendra Yadav5, N.S. Bugalia1 and R.P. Diwakar6
1Department of Veterinary Gynaecology and Obstetrics
2Department of Veterinary Medicine
3Department of Veterinary Surgery, (LUVAS, Hisar), India
4Disease investigation laboratory, Rohtak (LUVAS, Hisar), India
5RVDEC, Mahendergarh (LUVAS, Hisar), India
6Department of Veterinary Microbiology, C.V.Sc&A.H., N.D.U.A&T., Kumarganj, Faizabad (U.P), India
*Corresponding author
Abstract:

The present study was carried out in TVCC, Hisar on twenty-four dogs affected with venereal granuloma. Affected dogs were divided equally into three groups viz. vincristine therapy (Group I) with 7 day cycle and doxorubicin therapy consisting two groups i.e. Group IIwith 14 day cycleand group III with 21 day cycle. Blood sample collection was doneat weekly interval and before administration of drug i.e. Day 0,7,14 in Group I, Day 0,7,14,21,28 in Group II and Day 0,7,14,21,28,35,42 in Group III. Kidney Function Tests viz. Creatinine, Blood Urea Nitrogen , Total protein was undertaken for study.Non-significant effect of vincristine and doxorubicin recorded on serum total protein. Serum creatinine evidenced decreasing pattern in Group I.Serum creatinine values were slightly elevated till Day 14 and then declined till day 28 in Group II. Non-significant but continuous decreasing pattern was observed in Group III. BUN registered non-significant undulating trend in Group I, non-significant but continuous decreasing pattern in Group II and gradual increasing pattern from Day 7 to Day 28 and distinct drop till Day 42 in Group III.


Keywords: Creatinine, BUN,,Canine transmissible venereal tumor, Vincristine and Doxorubicin
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How to cite this article:

Anup Yadav, Praveen Kumar, Lokesh, Ashwani Kumar, Pankaj Kumar, Rajendra Yadav, N.S. Bugalia and Diwakar, R.P. 2018. Study of Kidney Function Tests in Pre and Post-treated Dogs on Chemotherapy with Doxorubicin and Vincristine in Venereal Granuloma.Int.J.Curr.Microbiol.App.Sci. 7(12): 740-745. doi: https://doi.org/10.20546/ijcmas.2018.712.091