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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(11): 3566-3539
DOI: https://doi.org/10.20546/ijcmas.2018.711.405


Genotoxicity Studies of Arsenic, Lead and Their Interaction in Wistar Rats
J. K. Raval*, Vikas Jaiswal, J. M. Patel, P. D. Vihol, H. C. Parmar, J. H. Patel and B. P. Joshi
Department of Veterinary Pathology, Vanbandhu College of Veterinary Science and A.H, Navsari Agricultural University – Navsari-396450, Gujarat, India
*Corresponding author
Abstract:

The present study was carried out on sixty Wistar rats divided into groups I, II, III, IV and V for a period of 28 days to study genotoxic effects induced by arsenic, lead and their mixture. The group I served as control while group II, III and IV were gavaged with sodium arsenite, lead acetate and mixture of both metals, respectively. The group V served as positive control which was treated with cyclophosphamide. Chromosomal aberration assay and micronuclei assay was studied from bone marrow cells of femur bone of all the rats. Arsenic and lead alone was equally genotoxic to that of mixture of both metals while their genotoxic potential was less than cyclophosphamide.


Keywords: Genotoxicity, Lead acetate, Sodium arsenite, Wistar rats
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How to cite this article:

Raval J. K., Vikas Jaiswal, J. M. Patel, P. D. Vihol, H. C. Parmar, J. H. Patel and Joshi B. P. 2018. Genotoxicity Studies of Arsenic, Lead and Their Interaction in Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 7(11): 3566-3539. doi: https://doi.org/10.20546/ijcmas.2018.711.405