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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(11): 3020-3029
DOI: https://doi.org/10.20546/ijcmas.2018.711.346


Prevalence of Metallo Β-Lactamase Producing Acinetobacter in Clinical Specimens from S.S.G. Hospital, Vadodara
Jignasha Tadvi1*, Jigna Karia2, Rachna Bhavasar3 and Hiral Patel4
1Department of Microbiology, Zydus Medical College & Hospital, Dahod, Gujarat, India
2Department of Microbiology, Baroda Medical College & SSG Hospital, Vadodara,
Gujarat, India
3Dr. M.K. Shah Medical College & Research Centre, Ahmedabad, Gujarat, India
4GMERS Medical College, Valsad, India
*Corresponding author
Abstract:

Acinetobacter species are the commonest pathogens causing nosocomial infections. Acinetobacter is essentially resistant to many antibiotics and they are known to produce extended spectrum beta lactamase and metalo beta lactamase. Aim of the study is to detect Metalo beta lactamase producing Acinetobacter spp. from clinical samples in tertiary care hospital. Between January 2015 to June 2015, total 368 Acinetobacter spp were isolated from different clinical samples. Antimicrobial susceptibility was done as per CLSI guideline. All imipenem resistant isolates were tested for MBL production by Imipenem - EDTA double disc synergy test (DDST) and Imipenem- EDTA combined disc test (CDT). Of 368 samples, majority of the Acinetobacter spp were isolated from blood 186(50.54%) followed by wound and pus samples 131 (35.6%). The isolation rate was highest from pediatric wards 192 (52.17%) and surgical wards 120 (32.61%). Total 368 samples, 14 (3.8%) isolates were MBL producer by CDST and DDST. Majority of the MBL producing Acinetobacter spp. were isolated from blood 5 (35.71%) followed by pus and wound 5 (35.71%). The isolation rate was highest from Pediatric wards 6 (42.90%) followed by the Surgical wards 5 (35.71%). Metallo-β-lactamase positive isolates of Acinetobacter spp. are important to identify because it poses therapeutic problems and serious concern for infection control management. There is also a need to emphasize on the rational use of antimicrobials and strictly adhere to the concept of “reserve drugs” to minimize the misuse of available antimicrobials.


Keywords: Metalo beta lactamase (MBL), Acinetobacter species
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How to cite this article:

Jignasha Tadvi, Jigna Karia, Rachna Bhavasar and Hiral Patel. 2018. Prevalence of Metallo Β-Lactamase Producing Acinetobacter in Clinical Specimens from S.S.G. Hospital, Vadodara.Int.J.Curr.Microbiol.App.Sci. 7(11): 3020-3029. doi: https://doi.org/10.20546/ijcmas.2018.711.346