National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Acinetobacter species are the commonest pathogens causing nosocomial infections. Acinetobacter is essentially resistant to many antibiotics and they are known to produce extended spectrum beta lactamase and metalo beta lactamase. Aim of the study is to detect Metalo beta lactamase producing Acinetobacter spp. from clinical samples in tertiary care hospital. Between January 2015 to June 2015, total 368 Acinetobacter spp were isolated from different clinical samples. Antimicrobial susceptibility was done as per CLSI guideline. All imipenem resistant isolates were tested for MBL production by Imipenem - EDTA double disc synergy test (DDST) and Imipenem- EDTA combined disc test (CDT). Of 368 samples, majority of the Acinetobacter spp were isolated from blood 186(50.54%) followed by wound and pus samples 131 (35.6%). The isolation rate was highest from pediatric wards 192 (52.17%) and surgical wards 120 (32.61%). Total 368 samples, 14 (3.8%) isolates were MBL producer by CDST and DDST. Majority of the MBL producing Acinetobacter spp. were isolated from blood 5 (35.71%) followed by pus and wound 5 (35.71%). The isolation rate was highest from Pediatric wards 6 (42.90%) followed by the Surgical wards 5 (35.71%). Metallo-β-lactamase positive isolates of Acinetobacter spp. are important to identify because it poses therapeutic problems and serious concern for infection control management. There is also a need to emphasize on the rational use of antimicrobials and strictly adhere to the concept of “reserve drugs” to minimize the misuse of available antimicrobials.
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