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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(11): 2814-2821
DOI: https://doi.org/10.20546/ijcmas.2018.711.324


Theileria-Induced Leukocyte Transformation: A Parasite Model for the Study of Lympho Proliferation
Aquil Mohmad1*, Bilal Ahmad Malla2, Ishfaq Maqbool3, Zahoor Ahmad War4, Irshad Ahmad Para5 and Sheikh Firdous Ahmad6
1Division of Parasitology
2Division of Veterinary Public Health
4Division of Veterinary Pathology
5Division of Physiology and climatology, Indian Veterinary Research Institute,
Izatnagar, Bareilly-243122, UP, India
3Department of Veterinary Parasitology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141004, Punjab, India
6Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar Bareilly 243122 UP India.6
*Corresponding author
Abstract:

The genus Theileria includes tick-transmitted Apicomplexan parasites of ruminants with substantial economic impact in endemic countries. Amongst the Apicomplexa phylum, Theileria is the only genus which transforms its mammalian host cells. Theileria parva and Theileria annulata infect leukocytes where they induce phenotypes that are shared with some cancers such as immortalization, dissemination and hyper proliferation. Transformation of lymphocytes is induced during the schizont stage. The mechanism of host cell transformation induces constitutive activation of bovine transcription factors (NF-kB) and associated signal transduction pathways. P53 plays an important role in proliferation and apoptosis and thus represents a key molecule in tumor formation. Moreover T. annulata schizonts induce a Warburg effect in host cells by a shift in ATP generation from predominantly oxidative phosphorylation to glycolysis and Theileria parasites avoids autophagic clearance by directly blocking autophagy. Theileria parasites secrete a protein, prolyl isomerase for maintaining the transformation of host cells. The host cell transformation by Theileria parasites and the comparison between cancer biology and host-Theileria interactions can help in revealing chemotherapeutic targets. This review is about host cell manipulation induced by Theileria parasites and the phenotypes, Theileria infected cells share with many cancers.


Keywords: Theileria parva and Theileria annulata, Exotic (taurine), P 53, immortalization, NF-kB
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How to cite this article:

Aquil Mohmad, Bilal Ahmad Malla, Ishfaq Maqbool, Zahoor Ahmad War, Irshad Ahmad Para and Sheikh Firdous Ahmad. 2018. Theileria-Induced Leukocyte Transformation: A Parasite Model for the Study of Lympho Proliferation.Int.J.Curr.Microbiol.App.Sci. 7(11): 2814-2821. doi: https://doi.org/10.20546/ijcmas.2018.711.324