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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(10): 3695-3703
DOI: https://doi.org/10.20546/ijcmas.2018.710.427


Effect of Nanosilver and Antibiotics Separately and in Combination on Pseudomonas aeruginosa Clinical Isolates
Alyousef Mansour Ali1*, Abdulaziz Ibrahim Alsenaid2, Ahmed Hassan Al-Mosilhi3,Fahad Ibrahim Al mofeez4, Jawaher Ahmad Almusailhi5, Raseel A. Awad6 and Waad Khalid Almusailhi6
1Consultant family and community medicine; moh, Saudi Arabia
2General Directorate of Health Affairs in Riyadh, Saudi Arabia
3MBBS, FFCM, Consultant Saudi Ministry of health
4General Directorate of Health Affairs in Riyadh, Ministry of Health, Saudi Arabia
5Medical student Imam Abdulrahman Alfaisal University, Dammam, KSA
6Medical student Al Maarefa college, Riyadh, KSA
*Corresponding author
Abstract:

The present study have been carried out to determine the Effect of Nanosilver and Antibiotics Separately and in Combination on Pseudomonas aeruginosa Clinical Isolates. There were Forty Pseudomonas aeruginosa were isolated from clinical specimens. The MicroScan WalkAway-96 SI System was used in laboratory Identification and antimicrobial susceptibility testing was performed. Also, the well diffusion method was used to evaluate the antibacterial activity of silver nanoparticles in combination with antibiotics.  All isolates were susceptible to more than MIC of nanosilver compared to a high resistance to multiple classes of antibiotics. The Average of inhibition zone diameters of different concentrations of nanosilver dilutions. The combined effect of the silver nanoparticles with antibiotics was assessed in comparison to antibiotics, with well diffusion method. It was observed that the collective effect of silver nanoparticles with antibiotics was additive. The activity of the three antibiotics: gentamycine. ampicillin, and tetracycline with nanoparticles, against Pseudomonas aeruginosa was shown as percentage enhancement in antibacterial effect. Silver nano particles may provide safe and effective treatment for MDR Pseudomonas aeruginosa infections when combined with antibiotics. More further studies are required for understand synergistic effect of nanosilver combining, Assessment of safety and efficacy of new antibiotic- nanosilver combination.


Keywords:  Nanosilver and Antibiotics, Pseudomonas aeruginosa
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How to cite this article:

Alyousef mansour Ali, Abdulaziz Ibrahim Alsenaid, Ahmed Hassan Al-Mosilhi, Fahad Ibrahim Al mofeez, Jawaher Ahmad Almusailhi, Raseel A. Awad and Waad Khalid Almusailhi. 2018. Effect of Nanosilver and Antibiotics Separately and in Combination on Pseudomonas aeruginosa Clinical Isolates.Int.J.Curr.Microbiol.App.Sci. 7(10): 3695-3703. doi: https://doi.org/10.20546/ijcmas.2018.710.427