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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(10): 2477-2483
DOI: https://doi.org/10.20546/ijcmas.2018.710.287


Effect of Ketoprofen Co-Administration and Febrile State on Pharmacokinetics of Levofloxacin in Goats Following Intravenous Administration
H. Patel Jatin1, D. Vihol Priti2, A. Sadariya Kamlesh4, D. Patel Urvesh3, D. Varia Rasesh1, K. Bhavsar Shailesh4 and M. Thaker Ashwin4
1Department of Pharmacology and Toxicology
2Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Navsari Agricultural University,
Navsari 396450, India
3Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh 362015, India
4Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand 388 001, India
*Corresponding author
Abstract:

The pharmacokinetic of levofloxacin (4 mg/kg) was studied following intravenous administration of levofloxacin in ketoprofen (3 mg/kg) treated and febrile (Lipopolysaccharide induced) goats. The concentration of levofloxacin in plasma was detected by using High Performance Liquid Chromatography. No significant changes were reported in pharmacokinetic parameters following co-administration of levofloxacin with ketoprofen. While under febrile state, significant increase in area under plasma curve and decrease in total body clearance were observed. Integrating the pooled pharmacokinetic data generated from the present study, levofloxacin via intravenous administration (4 mg/kg) repeated at 12 h interval is sufficient to maintain plasma concentration above the 0.05 g/mL MIC for most of the gram-positive and gram-negative microorganisms.


Keywords: Pharmacokinetic, Levofloxacin, Ketoprofen, Fever, Goat
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How to cite this article:

Patel Jatin, H., D. Vihol Priti, A. Sadariya Kamlesh, D. Patel Urvesh, D. Varia Rasesh, K. Bhavsar Shailesh and Thaker Ashwin, M. 2018. Effect of Ketoprofen Co-Administration and Febrile State on Pharmacokinetics of Levofloxacin in Goats Following Intravenous Administration.Int.J.Curr.Microbiol.App.Sci. 7(10): 2477-2483. doi: https://doi.org/10.20546/ijcmas.2018.710.287