National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The pharmacokinetic of levofloxacin (4 mg/kg) was studied following intravenous administration of levofloxacin in ketoprofen (3 mg/kg) treated and febrile (Lipopolysaccharide induced) goats. The concentration of levofloxacin in plasma was detected by using High Performance Liquid Chromatography. No significant changes were reported in pharmacokinetic parameters following co-administration of levofloxacin with ketoprofen. While under febrile state, significant increase in area under plasma curve and decrease in total body clearance were observed. Integrating the pooled pharmacokinetic data generated from the present study, levofloxacin via intravenous administration (4 mg/kg) repeated at 12 h interval is sufficient to maintain plasma concentration above the 0.05 ïÂÂg/mL MIC for most of the gram-positive and gram-negative microorganisms.
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