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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(10): 1562-1566
DOI: https://doi.org/10.20546/ijcmas.2018.710.175


Pharmacokinetic Activity of Quercetin in Rats Following Single Dose Intramuscular Administration
Falguni D. Modi1*, S.K. Bhavsar2, J.H. Patel1, R.D. Varia1, L.C. Modi3 and Megha Modi1
1Department of Veterinary Pharmacology and Toxicology
2Department of Veterinary Pharmacology and Toxicology
3Department of Veterinary Gynecology, College of Veterinary Sci. & A.H, Navsari Agricultural University, Navsari, Gujarat, India
*Corresponding author
Abstract:

Pharmacokinetic activity of Quercetin (100 mg/kg) was studied following intramuscular administration in rats. Drug concentration in rat plasma was determined using High Performance Liquid Chromatography (HPLC) following intramuscular administration of Quercetin (100 mg/kg) in rats. The pharmacokinetic parameters like the mean peak (Cmax) plasma drug concentration, time taken to reach the maximum concentration (Tmax), elimination half-life (t½), total body clearance (Cl(B)) and mean residence time (MRT) were 0.96  0.18 μg/mL, 0.25 0.02 h, 0.25  0.03 h, 356.53  36.63 L/h/kg and 0.43  0.04 h, respectively were determined.


Keywords: Pharmacokinetic, Quercetin, Rat
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How to cite this article:

Falguni D. Modi, S.K. Bhavsar, J.H. Patel, R.D. Varia, L.C. Modi and Megha Modi. 2018. Pharmacokinetic Activity of Quercetin in Rats Following Single Dose Intramuscular Administration.Int.J.Curr.Microbiol.App.Sci. 7(10): 1562-1566. doi: https://doi.org/10.20546/ijcmas.2018.710.175