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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(10): 606-618
DOI: https://doi.org/10.20546/ijcmas.2018.710.068


Six Transmembrane Epithelial Antigen of Prostate (STEAP1) Immunohistochemical Expression in Neoplastic and Non-Neoplastic Epithelial Lesion of Prostate
Fatma M.K.H. Ibrahim*, Elsayed A. Ali, Maha M.F. Shamloula, Mohamed M. Shareef and Asmaa E. Bedeer
Pathology Department, Faculty of Medicine, Tanta University, Egypt
*Corresponding author
Abstract:

Prostatic carcinoma is one of the most common malignancies in the world. Considering the incidence and the mortality of prostate cancer it seems important to study novel biomarkers for prostate cancer diagnosis and progression. Study the immunohistochemical expression of STEAP1 in prostatic adenocarcinoma, HGPIN and benign epithelial lesions of prostate stressing on its role in distinguishing prostatic carcinoma from its benign mimickers. STEAP1 expression was evaluated immunohistochemically in 30 cases of benign prostatic lesions, 8 cases of HGPIN and 40 cases of prostatic adenocarcinoma, and the results was correlated with clinicopathological and histopathological features. Significant difference was detected between STEAP1 expression in benign and malignant prostatic lesions, including prostatic adenocarcinoma and HGPIN, but no significant difference was detected between STEAP1 expression in prostatic carcinoma and HGPIN cases. Moreover, significant relationship was detected between STEAP1 expression and Gleason score of the adenocarcinoma cases. STEAP1 could be considered as an immunohistochemical marker with good sensitivity and considerable specificity for differentiating between benign and malignant prostatic lesions (HGPIN and prostatic adenocarcinoma) but it lacks specificity in distinguishing prostatic adenocarcinoma from HGPIN. STEAP1 might be considered as prognostic marker for prostatic adenocarcinoma and its overexpression was more associated with higher Gleason score.


Keywords: Prostatic adenocarcinoma, HGPIN, STEAP1, Immunohistochemistry, Mimickers of prostatic carcinoma
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How to cite this article:

Fatma, M.K.H. Ibrahim, Elsayed A. Ali, Maha M.F. Shamloula, Mohamed M. Shareef and Asmaa E. Bedeer. 2018. Six Transmembrane Epithelial Antigen of Prostate (STEAP1) Immunohistochemical Expression in Neoplastic and Non-Neoplastic Epithelial Lesion of Prostate.Int.J.Curr.Microbiol.App.Sci. 7(10): 606-618. doi: https://doi.org/10.20546/ijcmas.2018.710.068