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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2015: 85.95
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95
For more details click here
journals IJCMAS
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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(4): 2614-2622
DOI: https://doi.org/10.20546/ijcmas.2017.604.304


Hepatoprotective Efficacy of Picrorhiza kurroa in Experimentally induced Hepatotoxicity in Cockerels
Praveen Kumar1* and S.K. Shukla2
1Assistant Professor, Department of Veterinary Clinical Medicine, Ranchi Veterinary College, Kanke, Ranchi, Jharkhand 834006, India
2Department of Veterinary Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar 263145U.S. Nagar, Uttarakhand, India
*Corresponding author
Abstract:

Hepatoprotective properties of ethanolic and aqueous extracts of Picrorhiza kurroa rhizomes were evaluated in cockerels given acetaminophen @ 500 mg/ body weight orally to induce hepatocellular damage. Ethanolic extract given @ 50 mg/kg body wt and acetaminophen helped in restoration of Hb, PCV, TEC, TLC and lymphocytes and heterophils as well as total protein, albumin and globulin, glucose, cholesterol, bilirubin and activity of AST, ALT, ALP and LDH. Histopathological examination of liver section of treated birds clearly showed normal hepatic cells and central vein thereby confirming hepatoprotective activity. Silymarin used @ 200 mg/kg body weight as reference standard also showed the same results. Aqueous extract revealed the least activity. Phytochemical analysis of ethanolic extract showed presence of alkaloids, flavonoids, glycosides, protein, resin, saponin, sterol and tannins.


Keywords: Picrorhiza kurroa, Hepatoprotective activity, Biochemical profile,Cockerels.
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How to cite this article:

Praveen Kumar and Shukla, S.K. 2017. Hepatoprotective Efficacy of Picrorhiza kurroa in Experimentally induced Hepatotoxicity in Cockerels.Int.J.Curr.Microbiol.App.Sci. 6(4): 2614-2622. doi: https://doi.org/10.20546/ijcmas.2017.604.304