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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2015: 85.95
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95
For more details click here
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
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Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(4): . 977-986
DOI: https://doi.org/10.20546/ijcmas.2017.604.123


Scrub Typhus in Uttar Pradesh, India-A Prospective Study
Chandra Dev Pati Tripathi1, Mastan Singh1*, Jyotsna Agarwal1, Raj Kumar Kalyan1, Chandra Kanta2 and Virendra Atam3
1Department of Microbiology, King George’s Medical University,Lucknow-226003, Uttar Pradesh, India
2Department of Paediatrics, King George’s Medical University,Lucknow-226003, Uttar Pradesh, India
3Department of Internal Medicine, King George’s Medical University,Lucknow-226003, Uttar Pradesh, India
*Corresponding author
Abstract:

Scrub typhus (ST) is an acute febrile illness caused by Orientia tsutsugamushi, and is associated with considerable morbidity and mortality. ST has been considered as one of the most emerging infections in India as shown by the increase in the number of clinically diagnosed patients in various states except Uttar Pradesh. The present study was undertaken to look for ST amongst patients presenting with suggestive pyrexia of unknown origin (PUO) at a tertiary care centre in Uttar Pradesh. 324 serum samples from clinically suspected cases collected over a period of one year were analysed for the presence of rickettsial antibodies through Weil felix test and specific IgM antibodies against O. tsusugamushi by ELISA. Samples were also tested for other common causes of fever prevalent in this region. Eighty two (25.30%) sera were found to be positive for Weil feix test and 64 (19.75%) for IgM antibodies against O. tsusugamushi. Positivity was significantly higher among males (P < 0.05) between 0 and 15 yrs of age. The common symptoms noted were fever, myalgias, hepatosplenomegaly, and gastrointestinal complaints, followed by breathlessness, rash and jaundice. Fever was the most common manifestation (100%) and the pathognomonic feature; eschar was present only in 2 (3.1%) patients. Our results showed that scrub typhus should be considered in the differential diagnosis of acute febrile illness and empirical treatment with doxycycline may be given in cases with strong suspicion of scrub typhus.


Keywords: ELISA, Orientia tsusugamushi, Pyrexia of unknown origin (PUO), Scrub typhus, Weil Felix test.
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How to cite this article:

Chandra Dev Pati Tripathi, Mastan Singh, Jyotsna Agarwal, Raj Kumar Kalyan, Chandra Kanta, Virendra Atam. 2017. Scrub Typhus in Uttar Pradesh, India- A Prospective StudyInt.J.Curr.Microbiol.App.Sci. 6(4): . 977-986. doi: https://doi.org/10.20546/ijcmas.2017.604.123