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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2015: 85.95
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95
For more details click here
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(3): 1137-1145
DOI: https://doi.org/10.20546/ijcmas.2017.603.132


Microbiological Profile of Blood Stream Infection in Neutropenic Patient in a Tertiary Care Centre
Joydeep Mangaraj1* and Dipa Barkataki2
1Demonstrator
2Professor, M.D Microbiology, Gauhati Medical College, Assam, India  
*Corresponding author
Abstract:

Blood stream infection is a major cause of morbidity and mortality among neutropenic patients. Despite use of antibiotics and antifungals FN remains a therapeutic challenge. It prolongs hospital stay, increases health-care costs, and compromises chemotherapy efficacy in patients with malignancy who commonly experience neutropenia. This study depicts the microbiological profile, antibiotic sensitivity pattern and relation of BSI and degree of neutropenia in the neutropenic patients. The study was a hospital based prospective observational study conducted in a tertiary care centre in North east, India. Correlation of degree of neutropenia and BSI with analysis of microbiological profile and antibiotic sensitivity pattern of the FN patients admitted   from September 2014 to September 2016 was done. A total of 259 cases of fever with neutropenia were included from September 2014 to September 2016 in the present study. Of these, 55 (21.33%) were found to be culture positive. Majority of case 79 (30.5%) were suffering from Acute Myeloid Leukemia (AML). Gram negative bacilli 58.18 % (32) is the most common isolate. The antibiotic sensitivity among GNB was highest for colistin (100%) and teigecycline (93.8%). There is an alarming increase in resistance for cephalosporins and Carbapenems. The frequency of isolation of micro organisms in blood by blood culture in neutropenic patient with fever is 21.23% and Gram negative bacilli is still the predominant pathogens. There is an alarming rise in the resistance against carbapenems and commonly used drugs. It needs to be emphasized that a routine microbiological examination of these group of patients should be carried out routinely and periodically so as to analyse and compare the changing trends in the microbial aetiology and the antibiogram patterns. It is recommended that an effective empirical antibiotic regime could be tailored for this group of patients to decrease the morbidity and mortality. 


Keywords: Blood Stream Infection, Neutropenic Patient.
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How to cite this article:

Joydeep Mangaraj, Dipa Barkataki. 2017. Microbiological Profile of Blood Stream Infection in Neutropenic Patient in a Tertiary Care Centre.Int.J.Curr.Microbiol.App.Sci. 6(3): 1137-1145. doi: https://doi.org/10.20546/ijcmas.2017.603.132