National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Coronary artery diseases (CAD) are a global health problem. Its etiology is associated with various risk factors like hypertension, diabetes mellitus (DM) and dyslipidemia. Infections may represent an additive risk factor. The aim of the present study was to investigate the seroprevalence of specific immunoglobulins G for Chlamydia pneumoniae (C. pneumoniae) and Helicobacter pylori(H. pylori)among Patients admitted in intensive Coronary Care Unit of Mansoura university hospital. This study included 80 patients previously diagnosed to have CAD according to medical records and electrocardiographic (ECG) changes. The second group compromised 80 healthy control subjects. Samples from each subject were subjected to full biochemical laboratory tests, including complete lipid profile. Enzyme-linked immunosorbentassay (ELISA) was done for immunoglobulin (IgG) antibodies to H. pylori and C. pneumonia. Multiple logistic regression analysis were used to find out statistically significant results for H. pylori IgG and C. pneumoniae IgG and other conventional risk factors including; hypertension, diabetes, obesity and dyslipidaemia. Seroprevalence of specific IgG antibodies for C. pneumoniae and H. pylori showed significant increase in C. pneumoniae IgG and H. pylori IgG positivity among patients compared to control ( P value <0.001 and 0.015, respectively) .Analysis of risk factors associated with CAD revealed a significant association of C. pneumoniae IgG (P<0.001) and no association of H. pylori IgG (P=0.07) with CAD. Our study showed significant association between seropositivity of H. pylori and C. pneumoniae and CAD. Risk factors analysis for CAD revealed significant associations of CAD with hypertension, Diabetes mellitus (DM) and C. pneumoniae IgG.
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